DSpace JSPUI

Antimicrobial resistance is a global public health problem associated with an increase in infections caused by multidrug-resistant bacteria and a decrease in the effectiveness of available antibiotics. Staphylococcus aureus has been reported as one of the main pathogens in hospitals and communities, with a high prevalence of resistant strains. In Ecuador, studies show a growing resistance of S. aureus to methicillin, implying the need to explore new therapies. In this context, QSAR modeling a...

Last years, the highly pathogenic virus influenza A, particularly clade 2.3.4.4b, has spread globally, infecting wild birds, poultry, domestic animals, livestock, and wild animals, as well as humans, raising concerns about its zoonotic potential. Therefore, understanding its evolutionary dynamics and intercontinental dispersal patterns is essential for strengthening genomic surveillance. To this end, the present study analyzed 898 sequences available on GISAID, using temporal analysis and com...

Organic solid waste (OSW) is an abundant yet underutilized resource in the Metropolitan District of Quito (DMQ) that has significant potential for energy recovery through dark fermentation. This study evaluated the theoretical hydrogen production potential of local OSW using a method that integrated physicochemical characterization, 16S rRNA metagenomic analysis, functional inference with PICRUSt2, and process simulation with SuperPro Designer. Physicochemical and typological analyses rev...

Bacterial resistance to antibiotics represents one of the main challenges in global public health, which has driven research into new sources of bioactive compounds with antimicrobial activity, especially from natural products used in traditional medicine. The latex of Brosimum utile, known as Sande milk, has been used by indigenous communities to treat gastrointestinal conditions and ulcers and as a gastric protector; however, its antimicrobial potential has been little studied. The objec...